Poster Session - Abstract # 9

Design, Synthesis and Profiling of P-Heterocycles as Covalent Probes

Gaurav Garg, Paul R. Hanson

Department of Chemistry, The University of Kansas, Lawrence, KS, USA

Chemical probes are small molecules that are used to elucidate the biological functions of proteins.  In particular, covalent probes have emerged as valuable tools to advance our understanding of complex biological processes and pathways that are intimately involved in human health and diseases.  Within the realm of covalent probes, use of P-heterocycles is underexplored.  To address this gap, the development of a small library of P-heterocycles as covalent probes was envisioned.  The primary goal of the proposed work is the construction and assessment of P-heterocycles with varying reactivity patterns.  In this regard, modular synthetic routes employing P-linchpins are developed to construct electrophilic scaffolds with tunable electronic, steric, stereochemical, and cLogP properties.  Herein, the design, synthesis, and profiling of P-heterocycles as covalent probes will be presented.