Poster Session - Abstract # 27

The University of Kansas Protein Structure and X-ray Crystallography Laboratory

Steve Seibold , Lijun Liu, Anne Cooper and Scott Lovell

Protein Structure and X-Ray Crystallography Laboratory, University of Kansas, Lawrence, KS 66047

The Protein Structure and X-ray Crystallography Laboratory at The University of Kansas University (PSXL) collaborates with investigators from various institutions in an effort to obtain the 3-dimensional structures of proteins and small molecules using X-ray crystallography.  In addition, the PSXL serves as the main crystallography group for the Seattle Structural Genomics Center for Infectious Diseases (SSGCID) and is responsible for the structure determination of various proteins in the pipeline.  The capabilities along with examples of structures and ongoing NIH funded projects focused on drug development are presented.  These projects highlight the importance of obtaining structural information to provide mechanistic/functional insight for particular proteins and demonstrate the significance of structural biology to facilitate and support drug discovery efforts.