Abstract - Shyam Sathyamoorthi

Tethered Alkene Functionalization Technology for Complex Molecule Assembly

Advances in tethered olefin functionalization technology will greatly aid in the precise installation of alcohols and amines and in the efficient construction of stereochemical arrays.  In such reactions, a nucleophilic auxiliary (“the tether”) is appended to ubiquitous functional groups, usually alcohols or amines, followed by a cyclization event.  Because of geometric constraints on the transition states of intramolecular reactions, such cyclizations generally proceed with predictable regioselectivity and high diastereocontrol.  In this presentation, I will describe my laboratory’s development of several classes of tethered olefin functionalization reactions and their applications to complex antibiotic synthesis